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SLFN12 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IYM2 |
|---|---|
| Clone Names | 91230207 |
| Gene ID | 55106 |
|---|---|
| Other Names | Schlafen family member 12, SLFN12 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLFN12 (HGNC:25500) |
|---|---|
| Function | Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:35104454, PubMed:34272366, PubMed:34707099). May play a role in cell differentiation (PubMed:30045019). |
| Cellular Location | Nucleus. Cytoplasm, cytosol |
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Provided below are standard protocols that you may find useful for product applications.
Background
Belongs to the Schlafen family.
References
Schwarz, D.A., et al. Immunity 9(5):657-668(1998)
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