|Other Names||Ras GTPase-activating protein 4, Calcium-promoted Ras inactivator, Ras p21 protein activator 4, RasGAP-activating-like protein 2, RASA4, CAPRI, GAPL, KIAA0538|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAPRI, GAPL, KIAA0538|
|Function||Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.|
|Cellular Location||Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the GAP1 family ofGTPase-activating proteins that suppresses theRas/mitogen-activated protein kinase pathway in response to Ca(2+).Stimuli that increase intracellular Ca(2+) levels result in thetranslocation of this protein to the plasma membrane, where itactivates Ras GTPase activity. Consequently, Ras is converted fromthe active GTP-bound state to the inactive GDP-bound state and nolonger activates downstream pathways that regulate gene expression,cell growth, and differentiation. Multiple transcript variantsencoding different isoforms have been found for this gene.
Liu, Q., et al. J. Cell Biol. 170(2):183-190(2005)Minagawa, T., et al. Biochem. Biophys. Res. Commun. 288(1):87-90(2001)Lockyer, P.J., et al. Curr. Biol. 11(12):981-986(2001)
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