|Other Names||Chymotrypsin-like elastase family member 1, Elastase-1, Pancreatic elastase 1, CELA1, ELA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts upon elastin.|
|Tissue Location||Basal layers of epidermis (at protein level). Not expressed in the pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
Elastases form a subfamily of serine proteases thathydrolyze many proteins in addition to elastin. Humans have sixelastase genes which encode the structurally similar proteinselastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases,pancreatic elastase 1 is not expressed in the pancreas. To date,elastase 1 expression has only been detected in skin keratinocytes.Clinical literature that describes human elastase 1 activity in thepancreas or fecal material is actually referring tochymotrypsin-like elastase family, member 3B.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Talas, U., et al. J. Invest. Dermatol. 114(1):165-170(2000)
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