|Other Names||Solute carrier family 12 member 2, Basolateral Na-K-Cl symporter, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1, SLC12A2, NKCC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in many tissues.|
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Provided below are standard protocols that you may find useful for product applications.
By moving chloride into epithelial cells, the Na-K-Clcotransporter SLC12A2 aids transcellular movement of chlorideacross both secretory and absorptive epithelia (Payne et al., 1995[PubMed 7629105]). See also SLC12A1 (MIM 600839) and SLC12A3 (MIM600968).
Tang, J., et al. J. Biol. Chem. 285(44):34072-34085(2010)Helland, C.A., et al. Exp. Neurol. 224(2):424-428(2010)Sid, B., et al. J. Physiol. (Lond.) 588 (PT 13), 2315-2328 (2010) :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Orlov, S.N., et al. Curr. Opin. Nephrol. Hypertens. 19(2):163-168(2010)
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