|Other Names||Solute carrier family 12 member 2, Basolateral Na-K-Cl symporter, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1, SLC12A2, NKCC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in many tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
By moving chloride into epithelial cells, the Na-K-Clcotransporter SLC12A2 aids transcellular movement of chlorideacross both secretory and absorptive epithelia (Payne et al., 1995[PubMed 7629105]). See also SLC12A1 (MIM 600839) and SLC12A3 (MIM600968).
Tang, J., et al. J. Biol. Chem. 285(44):34072-34085(2010)Helland, C.A., et al. Exp. Neurol. 224(2):424-428(2010)Sid, B., et al. J. Physiol. (Lond.) 588 (PT 13), 2315-2328 (2010) :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Orlov, S.N., et al. Curr. Opin. Nephrol. Hypertens. 19(2):163-168(2010)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.