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LPXN Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O60711
Clone Names 100712096
Peptide ID 100712096
Additional Information
Gene ID 9404
Other Names Leupaxin, LPXN, LDLP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms LDLP
Function Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.
Cellular Location Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B- cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin
Tissue Location Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression
Research Areas
Citations (0)

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The product encoded by this gene is preferentiallyexpressed in hematopoietic cells and belongs to the paxillinprotein family. Similar to other members of thisfocal-adhesion-associated adaptor-protein family, it has fourleucine-rich LD-motifs in the N-terminus and four LIM domains inthe C-terminus. It may function in cell type-specific signaling byassociating with PYK2, a member of focal adhesion kinase family. Asa substrate for a tyrosine kinase in lymphoid cells, this proteinmay also function in, and be regulated by, tyrosine kinaseactivity. Alternative splicing results in multiple transcriptvariants encoding distinct isoforms.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Tanaka, T., et al. Cancer Sci. 101(2):363-368(2010)Dai, H.P., et al. Genes Chromosomes Cancer 48(12):1027-1036(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Sundberg-Smith, L.J., et al. Circ. Res. 102(12):1502-1511(2008)

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$ 80.00
Cat# BP17801c
Availability: In Stock
Bulk Size
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