|Other Names||ALX homeobox protein 1, Cartilage homeoprotein 1, CART-1, ALX1, CART1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509).|
|Tissue Location||Cartilage and cervix tissue.|
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The specific function of this gene has yet to bedetermined in humans; however, in rodents, it is necessary forsurvival of the forebrain mesenchyme and may also be involved indevelopment of the cervix. Mutations in the mouse gene lead toneural tube defects such as acrania and meroanencephaly. [providedby RefSeq].
Uz, E., et al. Am. J. Hum. Genet. 86(5):789-796(2010)Iioka, T., et al. J. Bone Miner. Res. 18(8):1419-1429(2003)Qu, S., et al. Development 126(2):359-369(1999)Cai, R.L. Biochem. Biophys. Res. Commun. 250(2):305-311(1998)Gordon, D.F., et al. DNA Cell Biol. 15(7):531-541(1996)
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