|Other Names||V-type proton ATPase subunit C 2, V-ATPase subunit C 2, Vacuolar proton pump subunit C 2, ATP6V1C2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.|
|Tissue Location||Kidney and placenta.|
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This gene encodes a component of vacuolar ATPase(V-ATPase), a multisubunit enzyme that mediates acidification ofeukaryotic intracellular organelles. V-ATPase dependent organelleacidification is necessary for such intracellular processes asprotein sorting, zymogen activation, receptor-mediated endocytosis,and synaptic vesicle proton gradient generation. V-ATPase iscomposed of a cytosolic V1 domain and a transmembrane V0 domain.The V1 domain consists of three A,three B, and two G subunits, aswell as a C, D, E, F, and H subunit. The V1 domain contains the ATPcatalytic site. This gene encodes alternate transcriptional splicevariants, encoding different V1 domain C subunit isoforms.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Gruber, G. Biochem. Soc. Trans. 33 (PT 4), 883-885 (2005) :Morel, N. Biol. Cell 95(7):453-457(2003)Smith, A.N., et al. Mol. Cell 12(4):801-803(2003)Kawasaki-Nishi, S., et al. FEBS Lett. 545(1):76-85(2003)
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