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NKX2-1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P43699
Clone Names 100427201
Peptide ID 100427201
Additional Information
Gene ID 7080
Other Names Homeobox protein Nkx-21, Homeobox protein NK-2 homolog A, Thyroid nuclear factor 1, Thyroid transcription factor 1, TTF-1, Thyroid-specific enhancer-binding protein, T/EBP, NKX2-1, NKX2A, TITF1, TTF1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NKX2-1 (HGNC:11825)
Function Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P50220}.
Tissue Location Thyroid and lung.
Research Areas
Citations (0)

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This gene encodes a protein initially identified as athyroid-specific transcription factor. The encoded protein binds tothyroglobulin promoter and regulates the expression ofthyroid-specific genes but has also been shown to regulate theexpression of genes involved in morphogenesis. Mutations anddeletions in this gene are associated with benign hereditarychorea, choreoathetosis, congenital hypothyroidism, and neonatalrespiratory distress, and may be associated with thyroid cancer.Multiple transcript variants encoding different isoforms have beenfound for this gene.


Kim, J.H., et al. Acta Cytol. 54(3):277-282(2010)Xu, B., et al. Appl. Immunohistochem. Mol. Morphol. 18(3):244-249(2010)Narumi, S., et al. J. Clin. Endocrinol. Metab. 95(4):1981-1985(2010)Guillot, L., et al. Hum. Mutat. 31 (2), E1146-E1162 (2010) :Cantara, S., et al. Thyroid Res 3 (1), 4 (2010) :

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$ 80.00
Cat# BP17825c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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