NKX2-1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P43699 |
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Clone Names | 100427201 |
Gene ID | 7080 |
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Other Names | Homeobox protein Nkx-21, Homeobox protein NK-2 homolog A, Thyroid nuclear factor 1, Thyroid transcription factor 1, TTF-1, Thyroid-specific enhancer-binding protein, T/EBP, NKX2-1, NKX2A, TITF1, TTF1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NKX2-1 (HGNC:11825) |
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Synonyms | NKX2A, TITF1, TTF1 |
Function | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P50220}. |
Tissue Location | Thyroid and lung. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein initially identified as athyroid-specific transcription factor. The encoded protein binds tothyroglobulin promoter and regulates the expression ofthyroid-specific genes but has also been shown to regulate theexpression of genes involved in morphogenesis. Mutations anddeletions in this gene are associated with benign hereditarychorea, choreoathetosis, congenital hypothyroidism, and neonatalrespiratory distress, and may be associated with thyroid cancer.Multiple transcript variants encoding different isoforms have beenfound for this gene.
References
Kim, J.H., et al. Acta Cytol. 54(3):277-282(2010)Xu, B., et al. Appl. Immunohistochem. Mol. Morphol. 18(3):244-249(2010)Narumi, S., et al. J. Clin. Endocrinol. Metab. 95(4):1981-1985(2010)Guillot, L., et al. Hum. Mutat. 31 (2), E1146-E1162 (2010) :Cantara, S., et al. Thyroid Res 3 (1), 4 (2010) :
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