|Other Names||Sex comb on midleg-like protein 2, SCML2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).|
|Tissue Location||Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.|
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This gene encodes a member of the Polycomb group proteins.These proteins form the Polycomb repressive complexes which areinvolved in transcriptional repression. The encoded protein bindshistone peptides that are monomethylated at lysine residues and maybe involved in regulating homeotic gene expression duringdevelopment.
Santiveri, C.M., et al. J. Mol. Biol. 382(5):1107-1112(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)Sathyamurthy, A., et al. J. Biol. Chem. 278(47):46968-46973(2003)Montini, E., et al. Genomics 58(1):65-72(1999)
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