KIAA0141 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q14154 |
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Clone Names | 110729114 |
Gene ID | 9812 |
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Other Names | Death ligand signal enhancer, KIAA0141, DELE |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DELE1 (HGNC:28969) |
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Function | Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency and mitochondrial stress (PubMed:32132706, PubMed:32132707, PubMed:35388015, PubMed:37327776). Detects impaired protein import and processing in mitochondria, activating the ISR (PubMed:35388015). May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation (PubMed:20563667). |
Cellular Location | [DAP3-binding cell death enhancer 1]: Mitochondrion. Mitochondrion outer membrane. Mitochondrion inner membrane. Note=Imported in the mitochondrial matrix in absence of stress, leading to its degradation by LONP1 (PubMed:37327776). Localizes at the mitochondrial surface in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting localization at the mitochondrial surface and stabilization (PubMed:37327776). Associates with the mitochondrion inner membrane in response to mitochondrial stress, leading to its proteolytic processing by OMA1, and generation of the AP3-binding cell death enhancer 1 short form (DELE1(S) or S-DELE1) (PubMed:32132707) |
Tissue Location | Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon |
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Provided below are standard protocols that you may find useful for product applications.
Background
KIAA0141 is detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon. It contains seven TPR repeats. Its function is unknown.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)Hoja, M.R., et al. Exp. Cell Res. 259(1):239-246(2000)
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