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LYPLA2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95372 |
|---|---|
| Clone Names | 110729132 |
| Gene ID | 11313 |
|---|---|
| Other Names | Acyl-protein thioesterase 2, APT-2, 312-, Lysophospholipase II, LPL-II, LysoPLA II, LYPLA2, APT2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LYPLA2 |
|---|---|
| Synonyms | APT2 |
| Function | Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2- arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in various breast cancer cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Lysophospholipases are enzymes that act on biologicalmembranes to regulate the multifunctional lysophospholipids. Thereare alternatively spliced transcript variants described for thisgene but the full length nature is not known yet. [provided byRefSeq].
References
Ma, J., et al. Atherosclerosis 191(1):63-72(2007)Wang, A., et al. Biochim. Biophys. Acta 1439(1):1-16(1999)
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