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NOTUM Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6P988 |
|---|---|
| Clone Names | 110729157 |
| Gene ID | 147111 |
|---|---|
| Other Names | Protein notum homolog, 3---, NOTUM |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NOTUM (HGNC:27106) |
|---|---|
| Function | Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q9VUX3}. |
| Tissue Location | Rarely expressed in adult normal tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
NOTUM may deacetylate GlcNAc residues on cell surface glycans (Potential).
References
Torisu, Y., et al. Cancer Sci. 99(6):1139-1146(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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