|Other Names||Cell differentiation protein RCD1 homolog, Rcd-1, CCR4-NOT transcription complex subunit 9, RQCD1, CNOT9, RCD1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.|
|Cellular Location||Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body|
|Tissue Location||Detected in spleen, thymus, prostate, testis, ovary and intestine.|
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Transcription factor that down-regulates MYB-and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A.
Ajiro, M., et al. Int. J. Oncol. 35(4):673-681(2009)Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)Garapaty, S., et al. J. Biol. Chem. 283(11):6806-6816(2008)Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007)Hiroi, N., et al. EMBO J. 21(19):5235-5244(2002)
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