|Other Names||THO complex subunit 3, Tho3, TEX1 homolog, hTREX45, THOC3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.|
|Cellular Location||Nucleus. Nucleus speckle|
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Provided below are standard protocols that you may find useful for product applications.
TEX1 is part of the TREX (transcription/export) complex,which includes THO2 (MIM 300395), HPR1 (MIM 606930), ALY (MIM604171), and UAP56 (MIM 142560).
Boyne, J.R., et al. PLoS Pathog. 4 (10), E1000194 (2008) :Cheng, H., et al. Cell 127(7):1389-1400(2006)Masuda, S., et al. Genes Dev. 19(13):1512-1517(2005)Guo, S., et al. Cancer Res. 65(8):3011-3016(2005)Strasser, K., et al. Nature 417(6886):304-308(2002)
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