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TRAF3IP1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TDR0 |
|---|---|
| Clone Names | 110808306 |
| Gene ID | 26146 |
|---|---|
| Other Names | TRAF3-interacting protein 1, Interleukin-13 receptor alpha 1-binding protein 1, Intraflagellar transport protein 54 homolog, Microtubule-interacting protein associated with TRAF3, MIP-T3, TRAF3IP1, IFT54, MIPT3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TRAF3IP1 |
|---|---|
| Synonyms | IFT54, MIPT3 |
| Function | Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q149C2}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q149C2}. Note=Microtubules (PubMed:12935900). In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip (PubMed:26487268) |
| Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TRAF3IP1 play an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Guo, C.W., et al. Proteomics 10(12):2337-2347(2010)Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)Tomppo, L., et al. Biol. Psychiatry 65(12):1055-1062(2009)Camargo, L.M., et al. Mol. Psychiatry 12(1):74-86(2007)
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