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TRAF3IP1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8TDR0
Clone Names 110808306
Peptide ID 110808306
Additional Information
Gene ID 26146
Other Names TRAF3-interacting protein 1, Interleukin-13 receptor alpha 1-binding protein 1, Intraflagellar transport protein 54 homolog, Microtubule-interacting protein associated with TRAF3, MIP-T3, TRAF3IP1, IFT54, MIPT3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRAF3IP1
Synonyms IFT54, MIPT3
Function Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity).
Cellular Location Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q149C2}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q149C2} Note=Microtubules (PubMed:12935900). In the cilium, it is observed at the ciliary base, ciliary transition zone and ciliary tip (PubMed:26487268).
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Background

TRAF3IP1 play an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Guo, C.W., et al. Proteomics 10(12):2337-2347(2010)Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)Tomppo, L., et al. Biol. Psychiatry 65(12):1055-1062(2009)Camargo, L.M., et al. Mol. Psychiatry 12(1):74-86(2007)

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$ 80.00
Cat# BP17861c
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