|Other Names||Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD40, CD40, TNFRSF5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.|
|Cellular Location||Isoform I: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||B-cells and in primary carcinomas.|
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The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor has been found to beessential in mediating a broad variety of immune and inflammatoryresponses including T cell-dependent immunoglobulin classswitching, memory B cell development, and germinal centerformation. AT-hook transcription factor AKNA is reported tocoordinately regulate the expression of this receptor and itsligand, which may be important for homotypic cell interactions.Adaptor protein TNFR2 interacts with this receptor and serves as amediator of the signal transduction. The interaction of thisreceptor and its ligand is found to be necessary foramyloid-beta-induced microglial activation, and thus is thought tobe an early event in Alzheimer disease pathogenesis. Twoalternatively spliced transcript variants of this gene encodingdistinct isoforms have been reported.
Rodriguez-Rodriguez, L., et al. J. Rheumatol. 37(10):2076-2080(2010)Lewis, J.P., et al. Genomics 96(4):211-219(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Blanco-Kelly, F., et al. PLoS ONE 5 (7), E11520 (2010) :Soliman, M.A., et al. Egypt J Immunol 16(1):61-70(2009)
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