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CD40 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P25942
Clone Names 90504030
Peptide ID 90504030
Additional Information
Gene ID 958
Other Names Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD40, CD40, TNFRSF5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD40
Synonyms TNFRSF5
Function Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Cellular Location Isoform I: Cell membrane; Single-pass type I membrane protein
Tissue Location B-cells and in primary carcinomas.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor has been found to beessential in mediating a broad variety of immune and inflammatoryresponses including T cell-dependent immunoglobulin classswitching, memory B cell development, and germinal centerformation. AT-hook transcription factor AKNA is reported tocoordinately regulate the expression of this receptor and itsligand, which may be important for homotypic cell interactions.Adaptor protein TNFR2 interacts with this receptor and serves as amediator of the signal transduction. The interaction of thisreceptor and its ligand is found to be necessary foramyloid-beta-induced microglial activation, and thus is thought tobe an early event in Alzheimer disease pathogenesis. Twoalternatively spliced transcript variants of this gene encodingdistinct isoforms have been reported.


Rodriguez-Rodriguez, L., et al. J. Rheumatol. 37(10):2076-2080(2010)Lewis, J.P., et al. Genomics 96(4):211-219(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Blanco-Kelly, F., et al. PLoS ONE 5 (7), E11520 (2010) :Soliman, M.A., et al. Egypt J Immunol 16(1):61-70(2009)

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$ 80.00
Cat# BP17871b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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