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CEACAM6 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P40199 |
|---|---|
| Clone Names | 90904043 |
| Gene ID | 4680 |
|---|---|
| Other Names | Carcinoembryonic antigen-related cell adhesion molecule 6, Non-specific crossreacting antigen, Normal cross-reacting antigen, CD66c, CEACAM6, NCA |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CEACAM6 |
|---|---|
| Synonyms | NCA |
| Function | Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:2803308, PubMed:2022629, PubMed:1378450, PubMed:8776764, PubMed:11590190, PubMed:10910050, PubMed:14724575, PubMed:16204051). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:2022629, PubMed:16204051). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:2803308, PubMed:2022629, PubMed:8776764, PubMed:11590190, PubMed:16204051). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion (PubMed:16204051). Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (PubMed:10910050, PubMed:14724575). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface. Note=Localized to the apical glycocalyx surface. |
| Tissue Location | Expressed in neutrophils (PubMed:1378450). Expressed in columnar epithelial and goblet cells of the colon (PubMed:10436421). Expressed in numerous tumor cell lines (at protein level) (PubMed:16204051). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Carcinoembryonic antigen (CEA; MIM 114890) is one of themost widely used tumor markers in serum immunoassay determinationsof carcinoma. An apparent lack of absolute cancer specificity forCEA probably results in part from the presence in normal andneoplastic tissues of antigens that share antigenic determinantswith the 180-kD form of CEA (Barnett et al., 1988 [PubMed3220478]). For background information on the CEA family of genes,see CEACAM1 (MIM 109770).
References
Wang, Y., et al. J. Clin. Invest. 119(6):1604-1615(2009)Kolla, V., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 296 (6), L1019-L1030 (2009) :Litkouhi, B., et al. Gynecol. Oncol. 109(2):234-239(2008)Owaidah, T.M., et al. Hematol Oncol Stem Cell Ther 1(1):34-37(2008)Skubitz, K.M., et al. J Transl Med 6, 78 (2008) :
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