|Other Names||Anaphase-promoting complex subunit 13, APC13, Cyclosome subunit 13, ANAPC13|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a component of the anaphase promotingcomplex, a large ubiquitin-protein ligase that controls cell cycleprogression by regulating the degradation of cell cycle regulatorssuch as B-type cyclins. The encoded protein is evolutionarilyconserved and is required for the integrity and ubiquitin ligaseactivity of the anaphase promoting complex. Pseudogenes and splicevariants have been found for this gene; however, the biologicalvalidity of some of the splice variants has not been determined.
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :Jin, L., et al. Cell 133(4):653-665(2008)Weedon, M.N., et al. Nat. Genet. 40(5):575-583(2008)Dube, P., et al. Mol. Cell 20(6):867-879(2005)Schwickart, M., et al. Mol. Cell. Biol. 24(8):3562-3576(2004)
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