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HTR2A Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P28223
Clone Names 90805040
Peptide ID 90805040
Additional Information
Gene ID 3356
Other Names 5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A, HTR2A, HTR2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTR2A
Synonyms HTR2
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Note=Localizes to the postsynaptic thickening of axo-dendritic synapses.
Tissue Location Detected in brain cortex (at protein level). Detected in blood platelets.
Research Areas
Citations (0)

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This gene encodes one of the receptors for serotonin, aneurotransmitter with many roles. Mutations in this gene areassociated with susceptibility to schizophrenia andobsessive-compulsive disorder, and are also associated withresponse to the antidepressant citalopram in patients with majordepressive disorder (MDD). MDD patients who also have a mutation inintron 2 of this gene show a significantly reduced response tocitalopram as this antidepressant downregulates expression of thisgene. Multiple transcript variants encoding different isoforms havebeen found for this gene.


Blaya, C., et al. Neurosci. Lett. 485(1):11-15(2010)Klein, A.B., et al. J. Cereb. Blood Flow Metab. 30 (11), E1-E7 (2010) :Borroto-Escuela, D.O., et al. Biochem. Biophys. Res. Commun. 401(4):605-610(2010)Terrazzino, S., et al. Headache (2010) In press :Kapelski, P., et al. Psychiatr. Pol. 44(2):197-206(2010)

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$ 80.00
Cat# BP17879c
(40 western blots)
Availability: In Stock
Bulk Size
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