HTR2A Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P28223 |
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Clone Names | 90805040 |
Gene ID | 3356 |
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Other Names | 5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A, HTR2A, HTR2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HTR2A |
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Synonyms | HTR2 |
Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2- aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:P35363}. Cell projection, axon {ECO:0000250|UniProtKB:P14842}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P14842}. Membrane, caveola {ECO:0000250|UniProtKB:P14842}. Presynapse {ECO:0000250|UniProtKB:P14842} |
Tissue Location | Detected in brain cortex (at protein level). Detected in blood platelets. |
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Background
This gene encodes one of the receptors for serotonin, aneurotransmitter with many roles. Mutations in this gene areassociated with susceptibility to schizophrenia andobsessive-compulsive disorder, and are also associated withresponse to the antidepressant citalopram in patients with majordepressive disorder (MDD). MDD patients who also have a mutation inintron 2 of this gene show a significantly reduced response tocitalopram as this antidepressant downregulates expression of thisgene. Multiple transcript variants encoding different isoforms havebeen found for this gene.
References
Blaya, C., et al. Neurosci. Lett. 485(1):11-15(2010)Klein, A.B., et al. J. Cereb. Blood Flow Metab. 30 (11), E1-E7 (2010) :Borroto-Escuela, D.O., et al. Biochem. Biophys. Res. Commun. 401(4):605-610(2010)Terrazzino, S., et al. Headache (2010) In press :Kapelski, P., et al. Psychiatr. Pol. 44(2):197-206(2010)
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