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RASSF1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NS23
Clone Names 90415014
Peptide ID 90415014
Additional Information
Gene ID 11186
Other Names Ras association domain-containing protein 1, RASSF1 {ECO:0000312|EMBL:AAF351282}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RASSF1 {ECO:0000312|EMBL:AAF35128.2}
Function Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Cellular Location Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells Colocalizes with MDM2 in the nucleus
Tissue Location Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.
Research Areas
Citations (0)

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This gene encodes a protein similar to the RAS effectorproteins. Loss or altered expression of this gene has beenassociated with the pathogenesis of a variety of cancers, whichsuggests the tumor suppressor function of this gene. Theinactivation of this gene was found to be correlated with thehypermethylation of its CpG-island promoter region. The encodedprotein was found to interact with DNA repair protein XPA. Theprotein was also shown to inhibit the accumulation of cyclin D1,and thus induce cell cycle arrest. Seven alternatively splicedtranscript variants of this gene encoding distinct isoforms havebeen reported.


El-Kalla, M., et al. Oncogene 29(42):5729-5740(2010)Vardi, A., et al. In Vivo 24(4):393-400(2010)Kim, J.H., et al. Virchows Arch. 457(1):35-42(2010)Ahmed, I.A., et al. Cancer Genet. Cytogenet. 199(2):96-100(2010)Zhang, H., et al. Zhongguo Fei Ai Za Zhi 13(4):311-316(2010)

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$ 80.00
Cat# BP17881c
(40 western blots)
Availability: In Stock
Bulk Size
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