|Other Names||Centromere protein O, CENP-O, Interphase centromere complex protein 36, CENPO, ICEN36, MCM21R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex.|
|Cellular Location||Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex|
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Provided below are standard protocols that you may find useful for product applications.
CENPO is a subunit of a CENPH (MIM 605607)-CENPI (MIM300065)-associated centromeric complex that targets CENPA (MIM117139) to centromeres and is required for proper kinetochorefunction and mitotic progression (Okada et al., 2006 [PubMed16622420]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Xin, X., et al. Genome Res. 19(7):1262-1269(2009)Saito, A., et al. J. Rheumatol. 36(4):781-786(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Izuta, H., et al. Genes Cells 11(6):673-684(2006)
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