AQP1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P29972 |
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Clone Names | 90819137 |
Gene ID | 358 |
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Other Names | Aquaporin-1, AQP-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, AQP1, CHIP28 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AQP1 (HGNC:633) |
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Synonyms | CHIP28 |
Function | Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:1373524). Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aquaporins are a family of small integral membraneproteins related to the major intrinsic protein (MIP or AQP0). Thisgene encodes an aquaporin which functions as a molecular waterchannel protein. It is a homotetramer with 6 bilayer spanningdomains and N-glycosylation sites. The protein physically resembleschannel proteins and is abundant in erythrocytes and renal tubes.The gene encoding this aquaporin is a possible candidate fordisorders involving imbalance in ocular fluid movement. Severaltranscript variants encoding different isoforms have been found forthis gene.
References
Chen, L.M., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 (5), R1163-R1174 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Shankardas, J., et al. Mol. Vis. 16, 1538-1548 (2010) :Halverson, G.R., et al. Immunohematology 26(1):22-26(2010)Sui, H., et al. Nature 414(6866):872-878(2001)
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