|Other Names||Aquaporin-1, AQP-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, AQP1, CHIP28|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.|
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Provided below are standard protocols that you may find useful for product applications.
Aquaporins are a family of small integral membraneproteins related to the major intrinsic protein (MIP or AQP0). Thisgene encodes an aquaporin which functions as a molecular waterchannel protein. It is a homotetramer with 6 bilayer spanningdomains and N-glycosylation sites. The protein physically resembleschannel proteins and is abundant in erythrocytes and renal tubes.The gene encoding this aquaporin is a possible candidate fordisorders involving imbalance in ocular fluid movement. Severaltranscript variants encoding different isoforms have been found forthis gene.
Chen, L.M., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 (5), R1163-R1174 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Shankardas, J., et al. Mol. Vis. 16, 1538-1548 (2010) :Halverson, G.R., et al. Immunohematology 26(1):22-26(2010)Sui, H., et al. Nature 414(6866):872-878(2001)
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