|Other Names||DNA repair protein complementing XP-G cells, 31--, DNA excision repair protein ERCC-5, Xeroderma pigmentosum group G-complementing protein, ERCC5, ERCM2, XPG, XPGC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ERCM2, XPG, XPGC|
|Function||Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.|
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Excision repair cross-complementing rodent repairdeficiency, complementation group 5 (xeroderma pigmentosum,complementation group G) is involved in excision repair ofUV-induced DNA damage. Mutations cause Cockayne syndrome, which ischaracterized by severe growth defects, mental retardation, andcachexia. Multiple alternatively spliced transcript variantsencoding distinct isoforms have been described, but the biologicalvalidity of all variants has not been determined. [provided byRefSeq].
Figl, A., et al. Mutat. Res. 702(1):8-16(2010)Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :Canbay, E., et al. Anticancer Res. 30(4):1359-1364(2010)
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