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AMTN Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6UX39 |
|---|---|
| Clone Names | 91208220 |
| Gene ID | 401138 |
|---|---|
| Other Names | Amelotin, AMTN |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | AMTN |
|---|---|
| Function | Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:Q9D3J8}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The mineralized portions of teeth, the dentin and enamel,are formed by mesenchyme-derived odontoblasts andepithelium-derived ameloblasts, respectively. As ameloblastsdifferentiate, they deposit specific proteins necessary for enamelformation, including amelogenin (AMELX; MIM 300391), enamelin(ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in theorganic enamel matrix. Amelotin is specifically expressed inmaturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed16304441]).
References
Moffatt, P., et al. Biochem. J. 399(1):37-46(2006)Iwasaki, K., et al. J. Dent. Res. 84(12):1127-1132(2005)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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