|Other Names||Amelotin, AMTN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
The mineralized portions of teeth, the dentin and enamel,are formed by mesenchyme-derived odontoblasts andepithelium-derived ameloblasts, respectively. As ameloblastsdifferentiate, they deposit specific proteins necessary for enamelformation, including amelogenin (AMELX; MIM 300391), enamelin(ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in theorganic enamel matrix. Amelotin is specifically expressed inmaturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed16304441]).
Moffatt, P., et al. Biochem. J. 399(1):37-46(2006)Iwasaki, K., et al. J. Dent. Res. 84(12):1127-1132(2005)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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