|Other Names||E3 ubiquitin-protein ligase MARCH3, 632-, Membrane-associated RING finger protein 3, Membrane-associated RING-CH protein III, MARCH-III, RING finger protein 173, MARCH3, RNF173|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.|
|Cellular Location||Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
MARCH3 is a member of the MARCH family of membrane-boundE3 ubiquitin ligases (EC 22.214.171.124). MARCH proteins add ubiquitin(see MIM 191339) to target lysines in substrate proteins, therebysignaling their vesicular transport between membrane compartments.MARCH3 appears to function in the endosomal recycling pathway(Fukuda et al., 2006 [PubMed 16428329]).
Fukuda, H., et al. J. Biochem. 139(1):137-145(2006)Bartee, E., et al. J. Virol. 78(3):1109-1120(2004)
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