|Other Names||Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, GPIa, VLA-2 subunit alpha, CD49b, ITGA2, CD49B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene product belongs to the integrin alpha chainfamily. Integrins are heterodimeric integral membrane glycoproteinscomposed of a distinct alpha chain and a common beta chain. Theyare found on a wide variety of cell types including, T cells,fibroblasts and platelets. Integrins are involved in cell adhesionand also participate in cell-surface mediated signalling. [providedby RefSeq].
Nie, Y.M., et al. Transfus Med 20(6):376-382(2010)Motovska, Z., et al. Atherosclerosis 212(2):548-552(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Hozumi, K., et al. FEBS Lett. 584(15):3381-3385(2010)Wang, Y., et al. Diabet. Med. 27(4):376-383(2010)
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