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ARHGEF18 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6ZSZ5 |
|---|---|
| Clone Names | 101109079 |
| Gene ID | 23370 |
|---|---|
| Other Names | Rho guanine nucleotide exchange factor 18, 114 kDa Rho-specific guanine nucleotide exchange factor, p114-Rho-GEF, p114RhoGEF, Septin-associated RhoGEF, SA-RhoGEF, ARHGEF18, KIAA0521 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ARHGEF18 |
|---|---|
| Synonyms | KIAA0521 |
| Function | Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Apical cell membrane. Note=In unactivated eosinophils, distributed around the cell periphery in the perimembranous region (PubMed:29601110). In activated eosinophils, relocates to the tip of the nucleopod, a membrane structure formed during activation when the nucleus moves to one end of the cell, and is also concentrated in membrane protrusions at the opposite end of the cell (PubMed:29601110) Localizes to the apical cell membrane in epithelial cells (PubMed:22006950). |
| Tissue Location | Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Isoform 1: Expressed in eosinophils (PubMed:29601110). Isoform 2: Expressed in eosinophils (PubMed:29601110). Isoform 3: Expressed in eosinophils (PubMed:29601110). Isoform 4: Not detected in eosinophils (PubMed:29601110). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Rho GTPases are GTP binding proteins that regulate a widespectrum of cellular functions. These cellular processes includecytoskeletal rearrangements, gene transcription, cell growth andmotility. Activation of Rho GTPases is under the direct control ofguanine nucleotide exchange factors (GEFs). The protein encoded bythis gene is a guanine nucleotide exchange factor and belongs tothe Rho GTPase GFE family. Family members share a common feature, aDbl (DH) homology domain followed by a pleckstrin (PH) homologydomain. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.
References
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)Niu, J., et al. Circ. Res. 93(9):848-856(2003)Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003) :Salehi, A.H., et al. J. Biol. Chem. 277(50):48043-48050(2002)Harrington, A.W., et al. J. Neurosci. 22(1):156-166(2002)
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