|Other Names||Musculin, Activated B-cell factor 1, ABF-1, Class A basic helix-loop-helix protein 22, bHLHa22, MSC, ABF1, BHLHA22|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.|
|Tissue Location||Expressed in lymphoid tissues, B-cell lines and activated B-cells|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a transcriptionalrepressor capable of binding an E-box element either as a homodimeror as a heterodimer with E2A in vitro. The encoded protein alsoforms heterodimers with E2A proteins in vivo. This protein iscapable of inhibiting the transactivation capability of E47, an E2Aprotein, in mammalian cells. This gene is a downstream target ofthe B-cell receptor signal transduction pathway. [provided byRefSeq].
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ushmorov, A., et al. Leukemia 22(10):1942-1944(2008)Knight, J.C., et al. Nat. Genet. 36(4):394-399(2004)Wong, J., et al. DNA Cell Biol. 20(8):465-471(2001)Robb, L., et al. Genomics 57(2):318-319(1999)
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