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SERTAD2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q14140 |
|---|---|
| Clone Names | 110726212 |
| Gene ID | 9792 |
|---|---|
| Other Names | SERTA domain-containing protein 2, Transcriptional regulator interacting with the PHD-bromodomain 2, TRIP-Br2, SERTAD2, KIAA0127 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SERTAD2 |
|---|---|
| Synonyms | KIAA0127, TRIPBR2 |
| Function | Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. |
| Cellular Location | Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome |
| Tissue Location | Expressed in adipose tissue. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SERTAD2 acts at E2F-responsive promoters to integrate signals provided by PHD-and/or bromodomain-containing transcription factors (By similarity).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Cheong, J.K., et al. J Transl Med 7, 8 (2009) :Cheong, J.K., et al. J. Biol. Chem. 283(17):11661-11676(2008)Watanabe-Fukunaga, R., et al. Genes Cells 10(8):851-860(2005)Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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