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EFCAB4B Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BSW2 |
|---|---|
| Clone Names | 110811066 |
| Gene ID | 84766 |
|---|---|
| Other Names | EF-hand calcium-binding domain-containing protein 4B, Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A, Calcium release-activated channel regulator 2A, CRACR2A, EFCAB4B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CRACR2A |
|---|---|
| Synonyms | EFCAB4B, RAB46 {ECO:0000303|PubMed:31092 |
| Function | [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. |
| Cellular Location | [Isoform 1]: Cytoplasm |
| Tissue Location | [Isoform 1]: Expressed in the Jurkat T-cell line. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
References
Chalasani, N., et al. Gastroenterology 139(5):1567-1576(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Srikanth, S., et al. Nat. Cell Biol. 12(5):436-446(2010)Aston, K.I., et al. J. Androl. 30(6):711-725(2009)Lim, J., et al. Cell 125(4):801-814(2006)
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