|Other Names||Gem-associated protein 8, Gemin-8, Protein FAM51A1, GEMIN8, FAM51A1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.|
|Cellular Location||Nucleus, gem. Cytoplasm. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm|
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The protein encoded by this gene is part of the SMNcomplex, which is necessary for spliceosomal snRNP assembly in thecytoplasm and pre-mRNA splicing in the nucleus. The encoded proteinbinds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediatingtheir interaction. This protein is found in nuclear Gemini of Cajalbodies (gems) and in the cytoplasm. Three transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].
Carissimi, C., et al. J. Biol. Chem. 281(48):37009-37016(2006)Carissimi, C., et al. J. Biol. Chem. 281(12):8126-8134(2006)
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