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GEMIN8 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NWZ8
Clone Names 110811083
Peptide ID 110811083
Additional Information
Gene ID 54960
Other Names Gem-associated protein 8, Gemin-8, Protein FAM51A1, GEMIN8, FAM51A1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FAM51A1
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Cellular Location Nucleus, gem. Cytoplasm. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm
Research Areas
Citations (0)

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The protein encoded by this gene is part of the SMNcomplex, which is necessary for spliceosomal snRNP assembly in thecytoplasm and pre-mRNA splicing in the nucleus. The encoded proteinbinds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediatingtheir interaction. This protein is found in nuclear Gemini of Cajalbodies (gems) and in the cytoplasm. Three transcript variantsencoding the same protein have been found for this gene. [providedby RefSeq].


Carissimi, C., et al. J. Biol. Chem. 281(48):37009-37016(2006)Carissimi, C., et al. J. Biol. Chem. 281(12):8126-8134(2006)

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$ 80.00
Cat# BP17974b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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