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GPR88 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9GZN0
Clone Names 110811091
Additional Information
Gene ID 54112
Other Names Probable G-protein coupled receptor 88, Striatum-specific G-protein coupled receptor, GPR88, STRG
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR88
Synonyms STRG
Function Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (PubMed:35501348). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (PubMed:23936473). In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (PubMed:23936473).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q9ESP4}; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q9ESP4}. Nucleus {ECO:0000250|UniProtKB:Q9ESP4}. Note=Localized to cilia in ciliated cells; whereas in non-ciliated cells, distributed throughout the cell membrane (PubMed:23936473). During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood {ECO:0000250|UniProtKB:Q9ESP4, ECO:0000269|PubMed:23936473}
Tissue Location Expressed predominantly in the striatum.
Research Areas
Citations (0)
citation

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Background

GPR88 is an orphan receptor.

References

Mizushima, K., et al. Genomics 69(3):314-321(2000)

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$ 277.78
Cat# BP17976b
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