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IFT27 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BW83 |
|---|---|
| Clone Names | 110811098 |
| Gene ID | 11020 |
|---|---|
| Other Names | Intraflagellar transport protein 27 homolog, Putative GTP-binding protein RAY-like, Rab-like protein 4, IFT27, RABL4, RAYL |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IFT27 |
|---|---|
| Synonyms | RABL4, RAYL |
| Function | Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). |
| Cellular Location | Cell projection, cilium. Cytoplasm {ECO:0000250|UniProtKB:Q9D0P8}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D0P8}. Note=Localizes to the sperm flagellum {ECO:0000250|UniProtKB:Q9D0P8} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a putative GTP-binding protein similarto RAY/RAB1C. The protein is ras-related, but the function isunknown. Several transcript variants encoding different isoformshave been found for this gene.
References
Qin, H., et al. Curr. Biol. 17(3):193-202(2007)Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :Collins, J.E., et al. Genome Res. 13(1):27-36(2003)Dunham, I., et al. Nature 402(6761):489-495(1999)
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