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CENPE Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q02224
Clone Names 80317146
Peptide ID 80317146
Additional Information
Gene ID 1062
Other Names Centromere-associated protein E, Centromere protein E, CENP-E, Kinesin-related protein CENPE, CENPE
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle.
Cellular Location Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division
Research Areas
Citations (0)

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Centrosome-associated protein E is a kinesin-like motorprotein that accumulates in the G2 phase of the cell cycle. Unlikeother centrosome-associated proteins, it is not present duringinterphase and first appears at the centromere region ofchromosomes during prometaphase. CENPE is proposed to be one of themotors responsible for mammalian chromosome movement and/or spindleelongation.


Kim, Y., et al. Cell 142(3):444-455(2010)Maia, A.F., et al. Chromosoma 119(4):405-413(2010)Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Maffini, S., et al. Curr. Biol. 19(18):1566-1572(2009)Liu, Z., et al. J. Exp. Clin. Cancer Res. 28, 156 (2009) :

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$ 80.00
Cat# BP17985b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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