|Other Names||Galectin-8, Gal-8, Po66 carbohydrate-binding protein, Po66-CBP, Prostate carcinoma tumor antigen 1, PCTA-1, LGALS8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Lectin with a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.|
|Tissue Location||Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy|
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This gene encodes a member of the galectin family.Galectins are beta-galactoside-binding animal lectins withconserved carbohydrate recognition domains. The galectins have beenimplicated in many essential functions including development,differentiation, cell-cell adhesion, cell-matrix interaction,growth regulation, apoptosis, and RNA splicing. This gene is widelyexpressed in tumoral tissues and seems to be involved inintegrin-like cell interactions. Alternatively spliced transcriptvariants encoding different isoforms have been identified.
Cludts, S., et al. Anticancer Res. 29(12):4933-4940(2009)Cueni, L.N., et al. Exp. Cell Res. 315(10):1715-1723(2009)Yoshida, H., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (PT 5), 512-514 (2009) :Massardo, L., et al. Lupus 18(6):539-546(2009)Savin, S., et al. Med. Oncol. 26(3):314-318(2009)
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