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RIP140 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P48552 |
|---|---|
| Clone Names | 90625063 |
| Gene ID | 8204 |
|---|---|
| Other Names | Nuclear receptor-interacting protein 1, Nuclear factor RIP140, Receptor-interacting protein 140, NRIP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NRIP1 |
|---|---|
| Function | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549). |
| Cellular Location | Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Nuclear receptor interacting protein 1 (NRIP1) is anuclear protein that specifically interacts with thehormone-dependent activation domain AF2 of nuclear receptors. Alsoknown as RIP140, this protein modulates transcriptional activity ofthe estrogen receptor.
References
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Docquier, A., et al. Clin. Cancer Res. 16(11):2959-2970(2010)Fritah, A., et al. Cardiovasc. Res. 86(3):443-451(2010)Suzuki, A., et al. J. Biol. Chem. 285(18):13444-13453(2010)
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