|Other Names||Nuclear receptor-interacting protein 1, Nuclear factor RIP140, Receptor-interacting protein 140, NRIP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.|
|Cellular Location||Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand- bound NR3C1|
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Provided below are standard protocols that you may find useful for product applications.
Nuclear receptor interacting protein 1 (NRIP1) is anuclear protein that specifically interacts with thehormone-dependent activation domain AF2 of nuclear receptors. Alsoknown as RIP140, this protein modulates transcriptional activity ofthe estrogen receptor.
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Docquier, A., et al. Clin. Cancer Res. 16(11):2959-2970(2010)Fritah, A., et al. Cardiovasc. Res. 86(3):443-451(2010)Suzuki, A., et al. J. Biol. Chem. 285(18):13444-13453(2010)
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