|Other Names||Histo-blood group ABO system transferase, Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Histo-blood group A transferase, A transferase, Histo-blood group B transferase, B transferase, NAGAT, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form, ABO|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes proteins related to the first discoveredblood group system, ABO. Which allele is present in an individualdetermines the blood group. The 'O' blood group is caused by adeletion of guanine-258 near the N-terminus of the protein whichresults in a frameshift and translation of an almost entirelydifferent protein. Individuals with the A, B, and AB allelesexpress glycosyltransferase activities that convert the H antigeninto the A or B antigen. Other minor alleles have been found forthis gene.
Thuresson, B., et al. Transfusion 48(3):493-504(2008)Seltsam, A., et al. Transfusion 47(12):2330-2335(2007)Twu, Y.C., et al. Transfusion 46(11):1988-1996(2006)Jenkins, P.V., et al. Transfusion 46(10):1836-1844(2006)Roubinet, F., et al. Transfusion 44(5):707-715(2004)
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