|Other Names||Golgi reassembly-stacking protein 1, Golgi peripheral membrane protein p65, Golgi phosphoprotein 5, GOLPH5, Golgi reassembly-stacking protein of 65 kDa, GRASP65, GORASP1, GOLPH5, GRASP65|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes.|
|Cellular Location||Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Undergoes rapid exchange with the cytosol|
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The Golgi complex plays a key role in the sorting andmodification of proteins exported from the endoplasmic reticulum.The protein encoded by this gene is a membrane protein involved inestablishing the stacked structure of the Golgi apparatus. It is acaspase-3 substrate, and cleavage of this encoded proteincontributes to Golgi fragmentation in apoptosis. This encodedprotein can form a complex with the Golgi matrix protein GOLGA2,and this complex binds to the vesicle docking protein p115. Severalalternatively spliced transcript variants of this gene have beenidentified, but their full-length natures have not been determined.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Tang, D., et al. Traffic 11(6):827-842(2010)Xiang, Y., et al. J. Cell Biol. 188(2):237-251(2010)D'Angelo, G., et al. J. Biol. Chem. 284(50):34849-34860(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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