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FARP1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y4F1 |
|---|---|
| Clone Names | 91009069 |
| Gene ID | 10160 |
|---|---|
| Other Names | FERM, RhoGEF and pleckstrin domain-containing protein 1, Chondrocyte-derived ezrin-like protein, Pleckstrin homology domain-containing family C member 2, PH domain-containing family C member 2, FARP1, CDEP, PLEKHC2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FARP1 |
|---|---|
| Synonyms | CDEP, PLEKHC2 |
| Function | Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). |
| Cellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Synapse. Synapse, synaptosome Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine. Note=Recruited to the cell membrane via interaction with CADM1. |
| Tissue Location | Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was originally isolated through subtractivehybridization due to its increased expression in differentiatedchondrocytes versus dedifferentiated chondrocytes. The resultingprotein contains a predicted ezrin-like domain, a Dbl homologydomain, and a pleckstrin homology domain. It is believed to be amember of the band 4.1 superfamily whose members link thecytoskeleton to the cell membrane. Two alternatively splicedtranscript variants encoding distinct isoforms have been found forthis gene.
References
Stein, J.L., et al. Neuroimage 53(3):1160-1174(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Evangelou, E., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1), 220-228 (2010) :Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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