|Other Names||FERM, RhoGEF and pleckstrin domain-containing protein 1, Chondrocyte-derived ezrin-like protein, Pleckstrin homology domain-containing family C member 2, PH domain-containing family C member 2, FARP1, CDEP, PLEKHC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine Note=Recruited to the cell membrane via interaction with CADM1|
|Tissue Location||Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung|
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This gene was originally isolated through subtractivehybridization due to its increased expression in differentiatedchondrocytes versus dedifferentiated chondrocytes. The resultingprotein contains a predicted ezrin-like domain, a Dbl homologydomain, and a pleckstrin homology domain. It is believed to be amember of the band 4.1 superfamily whose members link thecytoskeleton to the cell membrane. Two alternatively splicedtranscript variants encoding distinct isoforms have been found forthis gene.
Stein, J.L., et al. Neuroimage 53(3):1160-1174(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Evangelou, E., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1), 220-228 (2010) :Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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