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FUT9 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y231 |
|---|---|
| Clone Names | 91009137 |
| Gene ID | 10690 |
|---|---|
| Other Names | Alpha-(1, 3)-fucosyltransferase 9, 241-, Fucosyltransferase 9, Fucosyltransferase IX, Fuc-TIX, FucT-IX, Galactoside 3-L-fucosyltransferase, FUT9 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FUT9 {ECO:0000303|PubMed:10929005, ECO:0000312|HGNC:HGNC:4020} |
|---|---|
| Function | Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoproteins. Fucosylates distal type 2 LacNAc and its fucosylated (H-type 2 LacNAc) and sialylated (sialyl-type 2 LacNAc) derivatives to form Lewis x (Lex) (CD15) and Lewis y (Ley) antigenic epitopes involved in cell adhesion and differentiation (PubMed:10622713, PubMed:11278338, PubMed:12107078, PubMed:16282604, PubMed:17335083, PubMed:18395013, PubMed:23192350, PubMed:23263199, PubMed:29593094, PubMed:37202521, PubMed:10386598). Generates Lex epitopes in the brain, presumably playing a role in the maintenance of neuronal stemness and neurite outgrowth in progenitor neural cells (PubMed:17335083, PubMed:23000574) (By similarity). Fucosylates the internal type 2 LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (PubMed:23192350). Can also modify milk oligosaccharides, in particular type 2 tetrasaccharide LNnT (PubMed:37202521). |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6P4F1}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O88819} |
| Tissue Location | Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus (PubMed:10386598). Highly expressed in granulocytes. Not expressed in monocytes (PubMed:11278338). |
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Provided below are standard protocols that you may find useful for product applications.
Background
FUT9 is one of several alpha-3-fucosyltransferases thatcan catalyze the last step in the biosynthesis of Lewis antigen,the addition of a fucose to precursor polysaccharides. FUT9synthesizes the LeX oligosaccharide (CD15), which is expressed inorgan buds progressing in mesenchyma during humanembryogenesis.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Sikora, M., et al. Hum. Mol. Genet. 18(16):3136-3144(2009)Brito, C., et al. Biochimie 90(9):1279-1290(2008)Bogoevska, V., et al. Glycobiology 16(3):197-209(2006)Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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