|Other Names||Alpha-(1, 3)-fucosyltransferase 9, 241-, Fucosyltransferase 9, Fucosyltransferase IX, Fuc-TIX, FucT-IX, Galactoside 3-L-fucosyltransferase, FUT9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein Note=Membrane-bound form in trans cisternae of Golgi|
|Tissue Location||Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus.|
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Provided below are standard protocols that you may find useful for product applications.
FUT9 is one of several alpha-3-fucosyltransferases thatcan catalyze the last step in the biosynthesis of Lewis antigen,the addition of a fucose to precursor polysaccharides. FUT9synthesizes the LeX oligosaccharide (CD15), which is expressed inorgan buds progressing in mesenchyma during humanembryogenesis.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Sikora, M., et al. Hum. Mol. Genet. 18(16):3136-3144(2009)Brito, C., et al. Biochimie 90(9):1279-1290(2008)Bogoevska, V., et al. Glycobiology 16(3):197-209(2006)Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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