|Other Names||Glycerol-3-phosphate acyltransferase 3, GPAT-3, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10, AGPAT 10, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9, 1-AGP acyltransferase 9, 1-AGPAT 9, Acyl-CoA:glycerol-3-phosphate acyltransferase 3, hGPAT3, Lung cancer metastasis-associated protein 1, Lysophosphatidic acid acyltransferase theta, LPAAT-theta, MAG-1, AGPAT9, GPAT3, MAG1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid, or PA).|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein|
|Tissue Location||Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue|
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Provided below are standard protocols that you may find useful for product applications.
Glycerol-3-phosphate (G3P) acyltransferases (GPAT; EC22.214.171.124), such as GPAM (MIM 602395) and GPAT3, catalyze theinitial step of de novo triacylglycerol (TAG) synthesis byconverting glycerol-3-phosphate (G3P) to lysophosphatidic acid(LPA) (Cao et al., 2006 [PubMed 17170135]).
Shan, D., et al. J. Lipid Res. 51(7):1971-1981(2010)Cao, J., et al. Proc. Natl. Acad. Sci. U.S.A. 103(52):19695-19700(2006)Tang, W., et al. J. Biochem. Mol. Biol. 39(5):626-635(2006)Yamada, S., et al. Oncogene 23(35):5901-5911(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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