AGPAT9 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q53EU6 |
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Clone Names | 90909010 |
Gene ID | 84803 |
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Other Names | Glycerol-3-phosphate acyltransferase 3, GPAT-3, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10, AGPAT 10, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9, 1-AGP acyltransferase 9, 1-AGPAT 9, Acyl-CoA:glycerol-3-phosphate acyltransferase 3, hGPAT3, Lung cancer metastasis-associated protein 1, Lysophosphatidic acid acyltransferase theta, LPAAT-theta, MAG-1, AGPAT9, GPAT3, MAG1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GPAT3 (HGNC:28157) |
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Synonyms | AGPAT9, MAG1 |
Function | Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427). Protects cells against lipotoxicity (PubMed:30846318). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glycerol-3-phosphate (G3P) acyltransferases (GPAT; EC2.3.1.15), such as GPAM (MIM 602395) and GPAT3, catalyze theinitial step of de novo triacylglycerol (TAG) synthesis byconverting glycerol-3-phosphate (G3P) to lysophosphatidic acid(LPA) (Cao et al., 2006 [PubMed 17170135]).
References
Shan, D., et al. J. Lipid Res. 51(7):1971-1981(2010)Cao, J., et al. Proc. Natl. Acad. Sci. U.S.A. 103(52):19695-19700(2006)Tang, W., et al. J. Biochem. Mol. Biol. 39(5):626-635(2006)Yamada, S., et al. Oncogene 23(35):5901-5911(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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