|Other Names||C-myc promoter-binding protein, DENN domain-containing protein 4A, DENND4A, IRLB, MYCPBP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.|
|Tissue Location||Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner|
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Provided below are standard protocols that you may find useful for product applications.
DENND4A binds to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)Semova, N., et al. Genomics 82(3):343-354(2003)Stasiv, Y.Z., et al. Gene 145(2):267-272(1994)
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