|Other Names||Factor in the germline alpha, FIGalpha, Class C basic helix-loop-helix protein 8, bHLHc8, Folliculogenesis-specific basic helix-loop-helix protein, Transcription factor FIGa, FIGLA, BHLHC8|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.|
|Tissue Location||Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid- gestation, rising some 40-fold by the time of primordial follicle formation.|
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This gene encodes a protein that functions in postnataloocyte-specific gene expression. The protein is a basichelix-loop-helix transcription factor that regulates multipleoocyte-specific genes, including genes involved in folliculogenesisand those that encode the zona pellucida. Mutations in this genecause premature ovarian failure type 6.
van Dooren, M.F., et al. Curr. Opin. Obstet. Gynecol. 21(4):313-317(2009)Fowler, P.A., et al. J. Clin. Endocrinol. Metab. 94(4):1427-1435(2009)Tormala, R.M., et al. Mol. Cell. Endocrinol. 289 (1-2), 10-15 (2008) :Zhao, H., et al. Am. J. Hum. Genet. 82(6):1342-1348(2008)Suzumori, N., et al. Curr. Med. Chem. 14(3):353-357(2007)
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