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FZD7 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75084
Clone Names 91009141
Peptide ID 91009141
Additional Information
Gene ID 8324
Other Names Frizzled-7, Fz-7, hFz7, FzE3, FZD7
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD7
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas
Research Areas
Citations (0)

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Members of the 'frizzled' gene family encode7-transmembrane domain proteins that are receptors for Wntsignaling proteins. The FZD7 protein contains an N-terminal signalsequence, 10 cysteine residues typical of the cysteine-richextracellular domain of Fz family members, 7 putative transmembranedomains, and an intracellular C-terminal tail with a PDZdomain-binding motif. FZD7 gene expression may downregulate APCfunction and enhance beta-catenin-mediated signals in poorlydifferentiated human esophageal carcinomas.


Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Vincan, E., et al. Dev. Dyn. 239(1):311-317(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)Ueno, K., et al. Br. J. Cancer 101(8):1374-1381(2009)

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$ 80.00
Cat# BP18021c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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