|Other Names||Endothelial cell-specific chemotaxis regulator, Apoptosis regulator through modulating IAP expression, ARIA, Endothelial cell-specific molecule 2, ECSCR, ECSM2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cytoplasm|
|Tissue Location||Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is primarily found inendothelial cells and blood vessels, where it may be involved incell shape changes and EGF-induced cell migration. This gene couldplay a role in angiogenesis-related diseases.
Ikeda, K., et al. Proc. Natl. Acad. Sci. U.S.A. 106(20):8227-8232(2009)Ma, F., et al. Genes Cells 14(3):281-293(2009)Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :Armstrong, L.J., et al. Arterioscler. Thromb. Vasc. Biol. 28(9):1640-1646(2008)
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