|Other Names||Centrosomal protein of 120 kDa, Cep120, Coiled-coil domain-containing protein 100, CEP120, CCDC100|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo.|
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This gene encodes a protein that functions in themicrotubule-dependent coupling of the nucleus and the centrosome. Asimilar protein in mouse plays a role in both interkinetic nuclearmigration, which is a characteristic pattern of nuclear movement inneural progenitors, and in neural progenitor self-renewal.Mutations in this gene are predicted to result in neurogenicdefects. Alternative splicing results in multiple transcriptvariants.
Hutchins, J.R., et al. Science 328(5978):593-599(2010)Vasan, R.S., et al. JAMA 302(2):168-178(2009)Thorleifsson, G., et al. Nat. Genet. 41(1):18-24(2009)Xie, Z., et al. Neuron 56(1):79-93(2007)Guerrier, S., et al. Neuron 56(1):1-3(2007)
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