|Other Names||Centrosomal protein of 120 kDa, Cep120, Coiled-coil domain-containing protein 100, CEP120, CCDC100|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that functions in themicrotubule-dependent coupling of the nucleus and the centrosome. Asimilar protein in mouse plays a role in both interkinetic nuclearmigration, which is a characteristic pattern of nuclear movement inneural progenitors, and in neural progenitor self-renewal.Mutations in this gene are predicted to result in neurogenicdefects. Alternative splicing results in multiple transcriptvariants.
Hutchins, J.R., et al. Science 328(5978):593-599(2010)Vasan, R.S., et al. JAMA 302(2):168-178(2009)Thorleifsson, G., et al. Nat. Genet. 41(1):18-24(2009)Xie, Z., et al. Neuron 56(1):79-93(2007)Guerrier, S., et al. Neuron 56(1):1-3(2007)
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