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FXYD7 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P58549 |
|---|---|
| Clone Names | 91216215 |
| Gene ID | 53822 |
|---|---|
| Other Names | FXYD domain-containing ion transport regulator 7, FXYD7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FXYD7 |
|---|---|
| Cellular Location | Membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This reference sequence was derived from multiplereplicate ESTs and validated by similar human genomic sequence.This gene encodes a member of a family of small membrane proteinsthat share a 35-amino acid signature sequence domain, beginningwith the sequence PFXYD and containing 7 invariant and 6 highlyconserved amino acids. The approved human gene nomenclature for thefamily is FXYD-domain containing ion transport regulator.Transmembrane topology has been established for two family members(FXYD1 and FXYD2), with the N-terminus extracellular and theC-terminus on the cytoplasmic side of the membrane. FXYD2, alsoknown as the gamma subunit of the Na,K-ATPase, regulates theproperties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown toinduce channel activity in experimental expression systems. Thisgene product, FXYD7, is novel and has not been characterized as aprotein. [RefSeq curation by Kathleen J. Sweadner, Ph.D.,sweadner@helix.mgh.harvard.edu.].
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Beguin, P., et al. EMBO J. 21(13):3264-3273(2002)Sweadner, K.J., et al. Genomics 68(1):41-56(2000)Gale, M. Jr., et al. Mol. Cell. Biol. 18(2):859-871(1998)
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