|Other Names||FXYD domain-containing ion transport regulator 7, FXYD7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Single-pass membrane protein|
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This reference sequence was derived from multiplereplicate ESTs and validated by similar human genomic sequence.This gene encodes a member of a family of small membrane proteinsthat share a 35-amino acid signature sequence domain, beginningwith the sequence PFXYD and containing 7 invariant and 6 highlyconserved amino acids. The approved human gene nomenclature for thefamily is FXYD-domain containing ion transport regulator.Transmembrane topology has been established for two family members(FXYD1 and FXYD2), with the N-terminus extracellular and theC-terminus on the cytoplasmic side of the membrane. FXYD2, alsoknown as the gamma subunit of the Na,K-ATPase, regulates theproperties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown toinduce channel activity in experimental expression systems. Thisgene product, FXYD7, is novel and has not been characterized as aprotein. [RefSeq curation by Kathleen J. Sweadner, Ph.D.,firstname.lastname@example.org.].
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Beguin, P., et al. EMBO J. 21(13):3264-3273(2002)Sweadner, K.J., et al. Genomics 68(1):41-56(2000)Gale, M. Jr., et al. Mol. Cell. Biol. 18(2):859-871(1998)
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