|Other Names||Fanconi anemia group B protein, Protein FACB, Fanconi anemia-associated polypeptide of 95 kDa, FAAP95, FANCB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA repair protein required for FANCD2 ubiquitination.|
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Provided below are standard protocols that you may find useful for product applications.
The Fanconi anemia complementation group (FANC) currentlyincludes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2,FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCMand FANCN (also called PALB2). The previously defined group FANCHis the same as FANCA. Fanconi anemia is a genetically heterogeneousrecessive disorder characterized by cytogenetic instability,hypersensitivity to DNA crosslinking agents, increased chromosomalbreakage, and defective DNA repair. The members of the Fanconianemia complementation group do not share sequence similarity; theyare related by their assembly into a common nuclear proteincomplex. This gene encodes the protein for complementation group B.Alternative splicing results in two transcript variants encodingthe same protein.
Cheung, K.L., et al. World J Surg Oncol 8, 38 (2010) :Smith, I.M., et al. ORL J. Otorhinolaryngol. Relat. Spec. 72(1):44-50(2010)Barroso, E., et al. Breast Cancer Res. Treat. 118(3):655-660(2009)Garcia, M.J., et al. Breast Cancer Res. Treat. 113(3):545-551(2009)Nomura, Y., et al. Genes Cells 12(10):1111-1122(2007)
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