|Other Names||Endothelin-converting enzyme-like 1, 3424-, Xce protein, ECEL1, XCE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus, pancreas and skeletal muscle. Detected at very low levels in substantia nigra, cerebellum, cortex, corpus callosum and hippocampus|
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This gene encodes a member of the M13 family ofendopeptidases. In general, M13 family members are zinc-containingtype II integral-membrane proteins that are important regulators ofneuropeptide and peptide hormone activity. This gene is expressedspecifically in the central nervous system and its proteinlocalizes predominately to the endoplasmic reticulum or, in traceamounts, to the cell surface. Disruption of this gene in mouseembryonic stem cells results in neonatal lethality due torespiratory failure shortly after birth. Based on the specificexpression of this gene and the phenotype of the gene deficiency inmouse embryos, it is suggested that this protein plays a criticalrole in neural regulation of the respiratory system. This gene hasmultiple pseudogenes.
Kiryu-Seo, S., et al. J. Biol. Chem. 283(11):6988-6996(2008)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Benoit, A., et al. Biochem. J. 380 (PT 3), 881-888 (2004) :Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Kawamoto, T., et al. Int. J. Oncol. 22(4):815-822(2003)
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