|Other Names||Protein BEX3, Brain-expressed X-linked protein 3, Nerve growth factor receptor-associated protein 1, Ovarian granulosa cell 130 kDa protein HGR74, p75NTR-associated cell death executor, NGFRAP1, BEX3, DXS6984E, NADE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity).|
|Tissue Location||Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.|
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NGFRAP1 may be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.
Yasui, S., et al. Mol. Cell. Neurosci. 35(1):100-108(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Yu, Y., et al. Brain Res. 1100(1):13-20(2006)Alvarez, E., et al. Gene 357(1):18-28(2005)Ross, M.T., et al. Nature 434(7031):325-337(2005)
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